Below are some useful recipes. See also:

• Using AutoHotKey to map keys on the Amtelco KB163 Unified Keyboard.
• Using AutoHotkey to make a second mouse into a multimedia control

; General controls:
;   Win+Esc       to reload
;   Win+Shift+Esc to exit
;   Win+Ctrl+Esc  to exit
#Escape::Reload
#+Escape::ExitApp
#^Escape::Edit

; Win+Backtick = Sleep
#`::DllCall("PowrProf\SetSuspendState", "int", 0, "int", 0, "int", 0)

; Win+M = toggle mute
#m::Send {Volume_Mute}

Windows by default binds Win+X, Win+B, and Win+Space to stuff I don't care about. The script below will remap these to Win+Ctrl+<key>, which you can bind to apps without issue.

; WinAmp+Launchy remaps
#x::#^x
#b::#^b
#space::^#Space

; Auto mouse click: 
;  Win+Shift+I      to auto click slowly
;  Win+Shift+Ctrl+I to auto click quickly
;  Win+I            to auto stop
#+i::
SetTimer DoClick,500
SoundBeep 440,100
SoundBeep 660,100
return
#+^i::
SetTimer DoClick,50
SoundBeep 440,100
SoundBeep 660,100
SoundBeep 880,100
return
#i::
SetTimer DoClick,off
SoundBeep 660,100
SoundBeep 440,100
return
DoClick:
  Send {LButton}
  SoundBeep 200,10
return

The F5 for reload only works if the active file is the most recently opened.

; FoxIt keys: F5=reload
#IfWinActive, ahk_class classFoxitReader
F5::Send ^w!fr1
#IfWinActive

; Terraria: middle click is turbo left click
#IfWinActive, ahk_class WindowsForms10.Window.8.app.0.ea7f4a_r16_ad1
MButton::
	SetTimer DoClick,50
	SoundBeep 880,50
	return
MButton up::
	SetTimer DoClick,off
	SoundBeep 440,50
	return
#IfWinActive

The code below will replace the annoying help popup with a low-pitched beep. Change "SoundBeep…" to "Return" for silent operation.

; Suppress F1 in Explorer/Word/Excel -- replace the annoying help popup with a low-pitched beep
#IfWinActive ahk_class CabinetWClass
F1::SoundBeep 110,100
#IfWinActive ahk_class OpusApp
F1::SoundBeep 110,100
#IfWinActive ahk_class XLMAIN
F1::SoundBeep 110,100
#IfWinActive

; Ctrl+W = hold W (auto-run)
; Ctrl+LButton = hold LButton (auto-mine)
; Ctrl+RButton = hold RButton (auto-use)
; MButton = Sprint without double-tapping W
; Ctrl+MButton = hold MButton (auto-sprint)

#IfWinActive Minecraft ahk_class SunAwtFrame
^w::
 Send {w down}
 SoundBeep 500,100
 return

^LButton::
 Send {LButton down}
 SoundBeep 500,100
 return

^RButton::
 Send {RButton down}
 SoundBeep 500,100
 return

MButton:: 
 SetKeyDelay 55
 Send {w down}{w up}{w down}
 KeyWait MButton
 Send {w up}
 return

^MButton:: 
 SetKeyDelay 55
 Send {w down}{w up}{w down}
 SoundBeep 500,100
 return
#IfWinActive